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5.56 NATO vs. .223 Remington: Are They Really the Same? It's one of the most common questions in the shooting world, especially for AR-15 owners. The 5.56 NATO and .223 Remington cartridges look virtually identical, they're often sold side-by-side, and you see them discussed as if they're interchangeable. So, does it matter which one you use? The short, critical answer is no, they are not the same. While the cartridges share similar external dimensions, the primary differences lie in their inte …